Read BookDevelopment of Novel Anti-HIV Pyrimidobenzothiazine Derivatives (Springer Theses)

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The author successfully developed novel anti-HIV PD 404182 derivatives that exhibited submicromolar inhibitory activity against both HIV-1 and HIV-2. His thesis is in three parts. The first part expounds efficient methods for the synthesis of tricyclic heterocycles related to PD 404182 based on the sp2-carbon−heteroatom bond formations. Starting from arene or haloarene, C-O, C-N, or C-S bonds were formed by simply changing the reactants. These synthetic methods provide powerful approaches for the divergent preparation of pyrimido-benzoxazine, -quinazoline, or -benzothiazine derivatives. The second part explains SAR studies of PD 404182 for the development of anti-HIV agents. Through optimization studies of the central 1,3-thiazin-2-imine core, the benzene and cyclic amidine ring parts, 3-fold more potent inhibitors were obtained compared with the lead compound. The author also reveals by a time-of-drug-addition experiment that PD 404182 derivatives impaired HIV replication at the binding or fusion stage. The third part of the thesis elucidates the development of photoaffinity probes for the target identification of PD 404182. By the photolabeling experiment of HIV-1-infected H9 cells using these probes, the author detected proteins specifically bound to PD 404182. These new anti-HIV agents may be promising agents for anti-HIV therapy because their mechanisms of action differ from those of the currently approved anti-HIV agents. Development Of Novel Anti Hiv Pyrimidobenzothiazine Derivatives Development Of Novel Anti Hiv Pyrimidobenzothiazine ... Similar ebooks with Development Of Novel Anti Hiv Pyrimidobenzothiazine Derivatives : development of novel anti hiv ... springer theses recognizing outstanding ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives ... novel anti-HIV PD 404182 derivatives that ... Springer theses. schema:isSimilarTo http ... " Development of Novel Anti-HIV Pyrimidobenzothiazine ... Springer Theses Springer Game Development; Graphics; Hardware & Maker; Java; Machine Learning; Microsoft & .NET; Mobile; Networking & Cloud; Open Source; Programming; Python; Security; ... Springer Theses the best of the best ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives eBook ... Read Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives by Tsukasa Mizuhara with Kobo. ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives. ... Springer Theses . Thanks for Sharing! You ... ISBN: 9784431544449 - Development Of Novel Anti-HIV ... Book information and reviews for ISBN:9784431544449Development Of Novel Anti-HIV Pyrimidobenzothiazine Derivatives (Springer Theses) ... Development_Of_Novel_Anti_HIV_Pyrimidobenzothiazin.pdf; 4431544445.zip ... Development Of Novel Anti Hiv Pyrimidobenzothiazine Derivatives PDF ... Development Of Novel Anti Hiv Pyrimidobenzothiazine Derivatives PDF Document Author(s ... divergent synthetic methods of pyri Springer theses ... oishi shinya; ohno development of novel anti hiv ... Development of Novel Anti-HIV Pyrimidobenzothiazine - springer.com Development of Novel Anti-HIV Pyrimidobenzothiazine ... The author successfully developed novel anti-HIV PD 404182 derivatives ... The third part of the thesis elucidates the development of ... Springer Theses ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives ... Springer Theses. 2013. Development of Novel Anti ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives. ... Derivatives for the Highly Potent Anti-HIV ... Anti-HIV Pyrimidobenzothiazine Derivatives ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives ... Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives. ... developed novel anti-HIV PD 404182 derivatives that exhibited ... Springer Theses Recognizing Outstanding Ph.D ... of Novel Anti-HIV ... Development of Divergent Synthetic Methods of Pyrimidobenzothiazine ... Abstract. Cu(II)-mediated novel oxidative intermolecular ortho CH functionalization using tetrahydropyrimidine as the directing group has been investigated. Reaction of 2-phenyl-1456- tetrahydropyrimidine with ...
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